Hmm, I'll take a stab at the obvious so the smarter people around here can try the more esoteric stuff:

Is it hooked up via aux? Is the volume setting on the 2nd empeg normalized at 0 db and locked if so? Any weird equalizer settings? If you use Hijack to force AC mode while in the car does the problem still exist?

That's it, I think I'm out of obvious stuff...

-- Gary F.
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Eeyore, Original Owner -- Mk II 80 Gb, Blue S/N #090000803 Tigger, 2nd Owner -- Mk IIa, 80 Gb, Blue S/N #40103789