That all depends upon the software, I think. Linux USB 3.x has been somewhat unstable from time to time -- it seems to work well enough for me these days, but I only use it for removable drives.

The MediaSonic USB3/eSATA enclosures I have here are normally used in eSATA (port-multiplier) mode rather than USB3, simply because I don't want the extra complexity of USB3 conversion in the I/O path. More reliable and better, with Linux at least.

Cheers